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文献名称

邻近地区桥本甲状腺炎的相似及不同特性.影响甲状腺癌流行病学的可能原因 [下载]
 
Hashimoto’s Thyroiditis Similar and Dissimilar Characteristics in Neighboring Areas. Possible Implications for the Epidemiology of Thyroid Cancer
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文献简介

出版社:PLOS ONE

作者:Adele Latina1., Damiano Gullo1*., Francesco Trimarchi2, Salvatore Benvenga2,3

编号:10.1371/journal.pone.0055450

关键字:Hashimoto’s Thyroiditis,Thyroid Cancer

年份:2013点击量:1861

文献摘要

Context:

Medical centers worldwide report an increased frequency of Hashimoto’s thyroiditis (HT) and thyroid cancer (TC), two environmentally influenced diseases. In Sicily, data on HT are available for the province of Messina (1975–2005); data on TC are available for the whole island (2002–2004), with the volcanic province of Catania having the highest incidence.

引言:

医疗中心报道了全球桥本甲状腺炎(HT)和甲状腺癌(TC)的发病率均在增长,并且均受环境影响。在西西里,1975-2005年期间的HT数据可代表墨西拿的发病率,2002-2004年的TC数据则可代表整个岛屿的发病率,其中卡塔尼亚火山区的发病率最高。

 

Objective:

To replicate in Catania, on comparable years, the HT data of Messina.

目的:

本研文旨在研究在可比性年份中,莫西拿的HT数据与卡塔尼亚的重叠部分。

 

Design, Methods, Setting:

Review of the clinical records of patients in years 1995–2005 to compare presentation and yearly changes of HT. During 1995–2005, records were computer stored in the Endocrine Divisions of the University Hospitals of Catania and Messina, two tertiary referral centers.

设计,方法,设置:

本研究回顾了1995-2005年期间,患者的临床记录,以比较HT的临床表现和逐年的变化。这些记录通过电脑存储在卡塔尼亚和墨西拿大学医院的内分泌科室及二三级转诊中心。

 

Results:

Catania is outnumbered by Messina (742 vs. 3,409 HT patients). Similar were the linear increase in the yearly number of HT patients, rates of thyroid dysfunctions though with different proportions of subclinical and overt hypothyroidism, and rates of positiveness for TgAb or TPOAb. Different were age and its yearly trend; gender distribution and rates of the sonography variants, though yearly trends were similar.

结果:

结果显示,墨西拿(3409名)的HT患者远超于卡塔尼亚(742名),但相似的是两者的HT患者的年增长人数均呈线性增长。虽然其亚临床和临床甲状腺功能减退比例不同,但是甲状腺功能不全比率相似,并且TgAb或 TPOAb呈阳性率相似。另外,两者的年龄和年趋势存在差异,但性别分布和超声变种率则相似。

 

Conclusion:

The HT epidemics is smaller in Catania, with changes in presentation overlapping partially those in Messina.Whatever environmental factors might be involved, they (and/or their intensity) were not necessarily the same in these provinces. Intriguingly, the expected number of TC in HT patients with thyroid nodules in Catania is congruent with that of the general population of this province, but it is far less than in the Messina province. Thus, TC and HT incidences could be influenced by distinct environmental factors.

结论:

研究表明,卡塔尼亚的HT流行病与墨西拿的表现变化部分重叠,但发病率较小。可能会涉及环境因素,但这些省不一定相同。有趣的是,卡塔尼亚甲状腺结节合HT患者的TC患病率与普通人群一致。因此,TCHT发病率可能受不同环境因素的影响。

 


   

 

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