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文献名称

甲状旁腺功能减退症的全段甲状旁腺激素疗法 [下载]
 
Therapy of hypoparathyroidism with intact parathyroid hormone
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文献简介

出版社:Osteoporos Int

作者:M. R. Rubin, J. Sliney Jr., D. J. McMahon , S. J. Silverberg & J. P. Bilezikian

编号:10.1007/s00198-009-1149-x

关键字:Calcium;Hypoparathyroidism;PTH(1–84)

年份:2010点击量:812

文献摘要

Summary:

Hypoparathyroidism, a disorder characterized by low parathyroid hormone (PTH), is generally treated with oral calcium and vitamin D supplementation. We investigated the effects of PTH(1–84) treatment in 30 hypoparathyroid subjects for 24 months. PTH(1–84) treatment in hypoparathyroidism significantly reduced supplemental calcium and 1,25-dihydroxyvitamin D requirements without generally altering serum and urinary calcium levels.

总结:

甲状旁腺功能减退症,为一种甲状旁腺激素(PTH)低下的疾病,一般通过口服钙和维生素D进行补充。研究人员调查了30例经24个月PTH(1-84)治疗的甲状旁腺功能减退症受试者的疗效。研究表明,PTH(1-84)治疗甲状旁腺功能减退症明显减少了补充钙和1,25-二羟维生素D的需求,通常不改变血浆和尿钙水平。

 

Introduction:

Hypoparathyroidism, a disorder characterized by low PTH, is associated with hypocalcemia, hypercalciuria, and increased bone mineral density (BMD). Conventional therapy with calcium and 1,25-dihydroxyvitamin D can maintain the serum calcium concentration, but doses are high, and control is variable. We investigated the effects of human PTH(1–84) treatment in hypoparathyroidism.

前言:

甲状旁腺功能减退症,为一种PTH低下的疾病,与低血钙、高尿钙症和骨密度(BMD)的增加有关。钙和1,25二羟基维生素D的常规治疗可保持血清钙浓度,但剂量较高,并且无法控制变量。此外,研究人员还研究了人PTH(1-84)治疗甲状旁腺功能减退症的疗效。

 

Methods:

Thirty subjects with hypoparathyroidism were treated in an open-label study of PTH(1–84) 100 μg every other day by subcutaneous injection for 24 months, with monitoring of calcium and vitamin D supplementation requirements, serum and 24 h urinary calcium excretion, and BMD by dual energy X-ray absorptiometry.

方法:

在一个开放性研究中,30位甲状旁腺功能减退症受试者进行了隔日皮下注射100μg PTH(1-84)的治疗,为期24个月。期间,研究人员用双能X-线吸收仪监测了钙和维生素D的补充需求、血清和24小时尿钙排泄、以及骨密度。

 

Results:

Requirements for supplemental calcium decreased significantly (3,030±2,325 to 1,661±1,267 mg/day (mean±SD); p<0.05), as did requirements for supplemental 1,25- dihydroxyvitamin D (0.68±0.5 to 0.40±0.5 μg/day; p< 0.05). Serum calcium levels and 24 h urinary calcium excretion were mostly unchanged at 24 months. BMD increased at the lumbar spine by 2.9±4% from baseline (p<0.05), while femoral neck BMD remained unchanged and distal one third radial BMD decreased by 2.4±4% (p<0.05).

结果:

结果显示,补充钙的需求量显著下降(3,030±2,325 ~ 1,661±1,267 mg/天 (平均值±SD); P <0.05),同样,补充1,25二羟基维生素D的需求量也显著下降(0.68±0.5 ~ 0.40±0.5 μg/天; p< 0.05)。而血清钙水平和24h尿钙排泄量在24个月内基本维持不变。腰椎处的骨密度由基线水平上增长了2.9±4%(p<0.05),而股骨颈的骨密度维持不变,远端三分之一桡骨的骨密度下降了2.4±4%(P <0.05)

 

Conclusion:

PTH(1–84) treatment in hypoparathyroidism significantly reduces supplemental calcium and 1,25-dihydroxy vitamin D requirements without generally altering serum and urinary calcium levels.

结论:

研究指出,TH(1-84)治疗甲状旁腺功能减退症明显减少了补充钙和1,25-二羟维生素D的需求,但一般不改变血浆和尿钙水平。

   

 

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