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文献名称

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Refractory Idiopathic Non-Insulinoma Pancreatogenous Hypoglycemia in an Adult: Case Report and Review of the Literature
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文献简介

出版社:JOP. J Pancreas (Online)

作者:Cornelia Then1 , Yun-Chung Nam-Apostolopoulos 2 , Jochen Seissler 1 , Andreas Lechner 1

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年份:2013点击量:358

文献摘要

Context 

          Non-insulinoma pancreatogenous hypoglycemia is a rare cause of spontaneous hypoglycemia in adults. The ideal diagnostic and therapeutic approach is still controversial, not least because most reported cases lack long-term follow-up. 

Case report 

          We describe the case of a 58-year-old woman, who was diagnosed with idiopathic non-insulinoma pancreatogenous hypoglycemia in 2001. After resection of 75% of the distal pancreas, she initially experienced no additional hypoglycemic episodes and did not suffer from diabetes mellitus. However, after one month, recurrent hypoglycemia occurred. After resection of the larger part of the remaining pancreatic tissue, the patient suffered from hypoglycemic as well as hyperglycemic episodes. Octreotide and diazoxide were not successful in preventing the hypoglycemic attacks, whereas continuous insulin therapy with an insulin pump helped to stabilize the blood glucose level temporarily. Finally, all remaining pancreatic tissue had to be removed. Conclusion This  long-term follow-up of non-insulinoma pancreatogenous hypoglycemia treatment in an adult patient indicates that lateral  pancreatectomy may not be sufficient for permanent blood glucose control and emphasizes the need of follow-up data after subtotal  pancreatectomy. 

 

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