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A case report of non-islet cell tumour hypoglycaemia associated with ovarian germ-cell tumour
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文献简介

出版社:Palliative Medicine

作者:Louise Powter ,Suzanne Phillips,Emma Husbands

编号:10.1177/0269216312462273

关键字:Non-islet cell tumour hypoglycaemia, germ-cell tumour, hypoglycaemia, insulin-like growth factor-II, growth hormone, corticosteroids

年份:2012点击量:287

文献摘要

Background: 

          Non-islet cell tumour hypoglycaemia is a rare paraneoplastic condition in which tumours secrete a high-molecular-weight precursor of insulin-like growth factor-II causing hypoglycaemia and can be difficult to identify and treat.

Case Presentation: 

        This is the case of a 27-year-old patient from Africa with metastatic ovarian yolk sac tumour who presented with hypoglycaemia and was subsequently diagnosed with non-islet cell tumour hypoglycaemia.

Case Management: 

          Our patient required higher doses of glucocorticosteroids than reported in the literature in combination with recombinant growth hormone therapy in order to control her hypoglycaemia.

Case Outcome: 

          This is the first case of non-islet cell tumour hypoglycaemia described in association with a germ-cell tumour. Her management required collaboration between the endocrinology team, the palliative care team, the acute medicine team and physicians in Africa to enable her safe journey home.

Conclusions: 

          This case illustrates the need for awareness among general physicians of rare tumour manifestations and the need for multidisciplinary input for the optimal management of these patients.

 

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